Suppose that you believe in determinism, how could you live with that? Sometimes everything seems clearly determined by circumstances (science...), but it's hard to believe that someone who has murdered someone is not really guilty - 'it's the just the circumstances that influenced him to do such an act'. Or is there some kind of determinism where it is possible to be guilty? I hope you can help me out here.

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It is an open (and contentious) philosophical question whether determinism entails that we are not morally responsible for what we do. Many philosophers (the majority, I would guess) actually believe that moral responsibility is perfectly compatible with determinism. For such philosophers (often called compatibilists), whether you are blameworthy does not depend on whether the causal chain leading up to your action can be traced back to events that seem to have nothing to do with choices you've made. (After all, if determinism is true, all of your actions have such external causal origins.) Instead, according to compatibilists, whether you are blameworthy is a function of the particular shape that the causal chain leading up to your action takes. Of course, different compatibilists identify different features of the causal chain as the relevant ones, but they all agree that my action's being determined by antecendent events does not settle the question of whether I am morally responsible for that action.

Hobbes and Hume were two famous compatibilists. For an accessible and influential defense of compatibilism written by a well known contemporary philosopher, take a look at Daniel Dennett's Elbow Room.

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